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鼠神经生长因子治疗新生儿缺氧缺血性脑病的Meta 分析

发布日期:2016-07-21 点击次数:7808 字体显示:【大】  【中】  【小】

鼠神经生长因子治疗新生儿缺氧缺血性脑病的Meta 分析

【作者】 许马利;王杨

【作者单位】 安徽医科大学第一附属医院新生儿科,合肥230032

【摘要】 目的 观察鼠神经生长因子治疗新生儿缺氧缺血性脑病( HIE) 的有效性及安全性。方法 系统检索PubMed、EmBase、CoChrane、中国生物医学文献( CBM) 、万方、中国期刊全文、中文科技期刊全文数据库鼠神经生长因子( NGF)治疗HIE 的随机对照试验,从建库至2015 年10 月。按纳入标准进行筛选和质量评价,用RevMan 5. 3 软件进行Meta 分析。结果 共纳入8 项研究( 567 例) 。鼠神经生长因子试验组有效率、神经行为评分、神经心理发育评估和神经症状恢复时间与常规治疗组比较差异均有统计学意义( P < 0. 05) 。结论 鼠神经生长因子治疗HIE 较常规治疗效果更佳。

 

【Abstract】 Objective To evaluate the efficacy and safety of mouse nerve growth factor in the treatment of neonatal hypoxic - ischemic encephalopathy ( HIE) . Methods The randomized controlled trials about mouse nerve growth factor for HIE were searched systematically in PubMed,EmBase,Chinese Biomedical Literature Database ( CBM) , Cochrane controlled clinical trials database,Wanfang Data database of full - text journals,Chinese Journal Full - text Database,Chinese Science and Technology Journal Full - text database from their establishment to October 2015. According to the inclusion criteria,the trials were screened and quality assessment on them was performed, software RevMan 5. 3 was used for a Meta - analysis. Results Eight randomized controlled trials ( 567 cases) were eligible for inclusion in the study,The Meta analysis showed that there were statistically significant differences in efficiency,neurobehavioral scores,neuropsychological assessment and neurological development recovery time between mouse nerve growth factor treatment group and conventional treatment group. Conclusion For HIE, the treatment by mouse nerve growth factor has better efficacythan the conventional treatment.

 

【关键词】 鼠神经生长因子; 缺血缺氧性脑病; 新生儿; Meta 分析

【Keywords】mouse nerve growth factor; hypoxic - ischemic encephalopathy;newborn infants; Meta - analysis

DOI: 10. 13699 /j. cnki. 1001 - 6821. 2016. 07. 024