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注射用鼠神经生长因子联合血栓通治疗前部缺血性视神经病变的临床效果

发布日期:2016-07-21 点击次数:1820 字体显示:【大】  【中】  【小】

注射用鼠神经生长因子联合血栓通治疗前部缺血性视神经病变的临床效果

【作者】 周光华; 谢琼珺; 孙青青; 邓小湄; 文志聪; 罗平

【作者单位】 南方医科大学第五附属医院眼科,广州510900;赣南医学院,江西赣州341000

【摘要】 目的探讨注射用鼠神经生长因子联合血栓通治疗前部缺血性视神经病变的临床效果。方法选择2013 年1 月~2015 年12 月来我院治疗的前部缺血性视神经病变患者52 例,随机将其分为对照组和观察组各26 例。对照组使用常规药物治疗,而观察组以此为基础治疗,加用鼠神经生长因子,对比分析两组的临床治疗效果和视力恢复效果。结果观察组的视野恢复情况明显优于对照组,差异有统计学意义(P<0.05),且治疗后观察组视力提高例数明显高于对照组(P<0.05);观察组总有效率(96.15%)显著高于对照组76.92%,差异有统计学意义(P<0.05);观察组不良反应发生率(7.69%)显著低于对照组的23.08%,差异有统计学意义(P<0.05)。结论注射用鼠神经生长因子联合血栓通针对前部缺血性视神经病变患者进行治疗,临床疗效较佳,可有效恢复患者的视野,且与之相关的不良反应发生率较低,临床应用价值较大。

 

【Abstract】 Objective To explore the clinical effect of injection of mouse nerve growth factor combining with xueshuantongin the treatment of anterior ischemic optic neuropathy. Methods From January 2013 to December 2015,52 patients with anterior ischemic optic neuropathy who visited our hospital for treatments were selected, and were evenly divided into control group and observation group in random. In the control group, conventional drug therapy was used, while in the observation group, mouse nerve growth factor was added on the basis of conventional drug therapy. The clinical therapeutic effect and vision recovery were comparatively analyzed in two groups. Results Patients′ vision recovery in the observation group was much better than that in the control group with a statistical difference (P<0.05).The number of vision improvement in the observation group was larger than that in the control group (P<0.05).The total effective rate in the observation group was 96.15%,greatly higher than that in the control group (76.92%) with a statistical difference (P<0.05).The incidence of adverse reaction in the observation group was 7.69%,much lower in comparison with that in the control group accounting for 23.08%,which displayed a statistical difference (P<0.05). Conclusion Combination of injection of mouse nerve growth factor and xueshuantong can obtain a remarkable effect on treating anterior ischemic optic neuropathy. It can effectively recover patients′ vision in a low incidence of adverse reactions, which has a large value on clinical application.

 

【关键词】鼠神经生长因子;缺血性视神经病变;血栓通

【Keywords】Mouse nerve growth factor; Ischemic optic neuropathy ;Xueshuantong