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鼓室内注射鼠神经生长因子联合甲泼尼松龙治疗突发性聋的研究

发布日期:2016-12-14 点击次数:1975 字体显示:【大】  【中】  【小】

鼓室内注射鼠神经生长因子联合甲泼尼松龙治疗突发性聋的研究

【作者】 李征, 姚晨, 蔡晓航

【Author】 Li Zheng; Yao Chen; Cai Xiaohang

【作者单位】 南阳市第一人民医院耳鼻咽喉头颈外科;  南阳市第一人民医院心血管内二科;

 

【摘要】 目的:观察鼓室内注射鼠神经生长因子联合甲泼尼松龙治疗突发性聋的疗效。方法:将149例突发性聋患者随机分成2组,对照组常规治疗(扩张血管、改善微循环、营养神经、高压氧)加鼓室内注射甲泼尼龙(0.5ml)加生理盐水(0.5ml),每3d注射1次,连续2周。观察组常规治疗加鼓室内注射甲泼尼龙(0.5ml)加鼠神经生长因子(0.5ml),每3d注射1次,连续2周。结果:观察组听力、耳鸣、眩晕总有效率(93.4%、77.8%、85.2%)均分别优于对照组(80.8%、63.0%、67.2%),差异有统计学意义(P0.05)。结论:鼓室内注射鼠神经生长因子联合甲泼尼松治疗突发性聋疗效确切,能有效改善患者的听力、耳鸣和眩晕症状。

【Abstract】Objective To observe the efficacy of intratympanic injection with mouse nerve growth factor and methylprednisolone on the treatment of sudden deafness. Method One hundred and forty-nine patients diagnosed as sudden deafness were randomly divided into the control group and the observation group. The control group was treated with the conventional medication and methylprednisolone(0.5ml) + 0.9%NaCl(0.5ml), once every three dats for two weeks. The observation group was added with mouse nerve growth factor(0.5ml) once every three dats for two weeks. Result The total effective rate in the observation group of hearing, tinnitus and vertigo were respective 93.4%, 77.8%, 85.2%, which were higher than 80.8%, 63.0%, 67.2%, in the control group. And the differences between them had statistical significance(P<0.05). Conclusion Effect of the intratympanic injection with mouse growth factor and methylprednisolone on the treatment of sudden deafness is obvious, which can effectively improve hearing level, and relieve tinnitus and vertigo.

【关键词】 鼓室内注射,鼠神经生长因子,甲泼尼松龙,突发性聋

【Keywords】intratympanic injection; mouse nerve growth factor; methylprednisolone; sudden deafness

doi:10.13201/j.issn. 1001-1781.2016.21.016