【作者】 李征， 姚晨， 蔡晓航
【Author】 Li Zheng; Yao Chen; Cai Xiaohang
【作者单位】 南阳市第一人民医院耳鼻咽喉头颈外科; 南阳市第一人民医院心血管内二科;
【Abstract】Objective To observe the efficacy of intratympanic injection with mouse nerve growth factor and methylprednisolone on the treatment of sudden deafness. Method One hundred and forty-nine patients diagnosed as sudden deafness were randomly divided into the control group and the observation group. The control group was treated with the conventional medication and methylprednisolone(0.5ml) + 0.9%NaCl(0.5ml), once every three dats for two weeks. The observation group was added with mouse nerve growth factor(0.5ml) once every three dats for two weeks. Result The total effective rate in the observation group of hearing, tinnitus and vertigo were respective 93.4%, 77.8%, 85.2%, which were higher than 80.8%, 63.0%, 67.2%, in the control group. And the differences between them had statistical significance(P<0.05). Conclusion Effect of the intratympanic injection with mouse growth factor and methylprednisolone on the treatment of sudden deafness is obvious, which can effectively improve hearing level, and relieve tinnitus and vertigo.
【Keywords】intratympanic injection; mouse nerve growth factor; methylprednisolone; sudden deafness